achim kramer lab

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Journal clubs take place Fridays at 10:00 am: CCO Virchowweg 6, 4th floor, seminar room 5
The old seminar-files can be found here: 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016,



21.12.2018: Christian




14.12.2018: Bert




07.12.2018: Seminar instead of JC: Neta's thesis defense rehearsal



30.11.2018: ITB workshop instead of JC (ITB Haus 4 Seminarraum 14:00-17:00)



23.11.2018: Ashraf
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.
Lananna BV1, Nadarajah CJ1, Izumo M2, Cedeño MR1, Xiong DD1, Dimitry J1, Tso CF3, McKee CA1, Griffin P1, Sheehan PW1, Haspel JA4, Barres BA5, Liddelow SA6, Takahashi JS7, Karatsoreos IN8, Musiek ES9.
Cell Rep. 2018 Oct 2;25(1):1-9.e5. doi: 10.1016/j.celrep.2018.09.015.

16.11.2018: clock meeting Mainz: JC canceled



09.11.2018: Anna
YAP1 enhances NF-kB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma.
Rivera-Reyes A1, Ye S1, E Marino G1, Egolf S1, E Ciotti G1, Chor S1, Liu Y1, Posimo JM1,2, Park PMC3, Pak K1, Babichev Y4,5, Sostre-Colón J1, Tameire F6, Leli NM6, Koumenis C6, C Brady D1,2, Mancuso A7, Weber K8, Gladdy R4,5, Qi J3, Eisinger-Mathason TSK9.
Cell Death Dis. 2018 Oct 31;9(11):1108. doi: 10.1038/s41419-018-1142-4.

07.11.2018: Journal club instead of seminar: Muge
Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates
Cristina Pagano,1,3 Rima Siauciunaite,1 Maria L. Idda,1,4 Gennaro Ruggiero,1 Rosa M. Ceinos,1,2,5 Martina Pagano,1,6 Elena Frigato,2 Cristiano Bertolucci,2 Nicholas S. Foulkes,corresponding author1 and Daniela Vallonecorresponding author1
Sci Rep. 2018; 8: 13180.Published online 2018 Sep 4. doi: [10.1038/s41598-018-31570-8]

02.11.2018: canceled




26.10.2018: Sebastian F.
Circadian clock component REV-ERBa controls homeostatic regulation of pulmonary inflammation.
Pariollaud M1, Gibbs JE1, Hopwood TW1, Brown S1, Begley N1, Vonslow R1, Poolman T1, Guo B1, Saer B1, Jones DH2, Tellam JP2, Bresciani S2, Tomkinson NC2, Wojno-Picon J2,3, Cooper AW2,3, Daniels DA3, Trump RP4, Grant D4,5, Zuercher W4,6, Willson TM4,6, MacDonald AS1, Bolognese B7, Podolin PL7, Sanchez Y7, Loudon AS1, Ray DW1.
J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.

19.10.2018: Achim
paper of special interest



12.10.2018: Nikhil
Two coupled circadian oscillations regulate Bmal1-ELuc and Per2-SLR2 expression in the mouse suprachiasmatic nucleus.
Nishide S1,2, Honma S3, Honma KI4.
Sci Rep. 2018 Oct 3;8(1):14765. doi: 10.1038/s41598-018-32516-w.

05.10.2018: special lab meeting: cell culture SOP



28.10.2018: Manon
paper of special interest



21.09.2018: Marta
ASK family kinases mediate cellular stress and redox signaling to circadian clock.
Imamura K1, Yoshitane H2, Hattori K3, Yamaguchi M1, Yoshida K1, Okubo T1, Naguro I3, Ichijo H3, Fukada Y2.
Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3646-3651. doi: 10.1073/pnas.1719298115. Epub 2018 Mar 19.

14.09.2018: seminar instead of journal club (Bert)



12.09.2018: journal club instead of seminar (Christian)
Long-term in vivo recording of circadian rhythms in brains of freely moving mice.
Mei L1,2, Fan Y2, Lv X3,4, Welsh DK5,6, Zhan C7, Zhang EE7.
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4276-4281. doi: 10.1073/pnas.1717735115. Epub 2018 Apr 2.

07.09.2018: Bert
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.
Deng W1, Zhu S2, Zeng L3, Liu J2, Kang R4, Yang M5, Cao L5, Wang H6, Billiar TR4, Jiang J3, Xie M7, Tang D8.
Cell Rep. 2018 Jul 10;24(2):366-378. doi: 10.1016/j.celrep.2018.06.026.

31.08.2018: Abhi
A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa.
Ratnayake L1, Adhvaryu KK1, Kafes E1, Motavaze K1, Lakin-Thomas P1.
PLoS Genet. 2018 Jun 20;14(6):e1007457. doi: 10.1371/journal.pgen.1007457. eCollection 2018 Jun.

24.08.2018: Marina
Dissociation of Per1 and Bmal1 circadian rhythms in the suprachiasmatic nucleus in parallel with behavioral outputs.
Ono D1, Honma S2, Nakajima Y3, Kuroda S4, Enoki R5,6,7, Honma KI6.
Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3699-E3708. doi: 10.1073/pnas.1613374114. Epub 2017 Apr 17.

17.08.2018: Bharath
Identification of circadian clock modulators from existing drugs.
Tamai TK1, Nakane Y1,2, Ota W1,2, Kobayashi A1,2, Ishiguro M1,2, Kadofusa N1, Ikegami K3, Yagita K4, Shigeyoshi Y3, Sudo M1, Nishiwaki-Ohkawa T1,2, Sato A1, Yoshimura T5,2,6,7.
EMBO Mol Med. 2018 May;10(5). pii: e8724. doi: 10.15252/emmm.201708724.

10.08.2018: canceled



03.08.2018: Anna
Sleeping sickness is a circadian disorder.
Rijo-Ferreira F1,2,3,4, Carvalho T2, Afonso C5, Sanches-Vaz M2, Costa RM5, Figueiredo LM6, Takahashi JS7,8.
Nat Commun. 2018 Jan 4;9(1):62. doi: 10.1038/s41467-017-02484-2.

27.07.2018: Achim
Tracking urban human activity from mobile phone calling patterns.
Monsivais D1, Ghosh A1, Bhattacharya K1, Dunbar RIM1,2, Kaski K1,2.
PLoS Comput Biol. 2017 Nov 21;13(11):e1005824. doi: 10.1371/journal.pcbi.1005824. eCollection 2017 Nov.

20.07.2018: Ashraf
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.
Katada S1, Sassone-Corsi P.
Nat Struct Mol Biol. 2010 Dec;17(12):1414-21. doi: 10.1038/nsmb.1961. Epub 2010 Nov 28.

13.07.2018: Carola
CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues.
Luciano AK1,2, Zhou W3,2, Santana JM1,2, Kyriakides C1,2, Velazquez H4, Sessa WC5,2.
J Biol Chem. 2018 Jun 8;293(23):9126-9136. doi: 10.1074/jbc.RA117.000773. Epub 2018 Mar 27.

06.07.2018: Nikhil
CK1d/e protein kinase primes the PER2 circadian phosphoswitch
Rajesh Narasimamurthy,a Sabrina R. Hunt,b Yining Lu,c,d Jean-Michel Fustin,e Hitoshi Okamura,e Carrie L. Partch,b,f Daniel B. Forger,c,d,g Jae Kyoung Kim,h and David M. Virshupa,i,1
Proceedings of the National Academy of Sciences of the United States of America, 115(23), 5986–5991. http://doi.org/10.1073/pnas.1721076115

29.06.2018: Matthias
Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules.
Khalyfa A1, Poroyko VA1, Qiao Z1, Gileles-Hillel A1, Khalyfa AA1, Akbarpour M1, Almendros I2,3,4, Farré R2,3,4, Gozal D1.
Front Physiol. 2017 Nov 2;8:882. doi: 10.3389/fphys.2017.00882. eCollection 2017.

22.06.2018: Seminar instead of JC: Adrian Granada



20.06.2018: Marta
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
Wible RS#1,2, Ramanathan C#3, Sutter CH2,3, Olesen KM3, Kensler TW4, Liu AC#2,3, Sutter TR#1,2,3.
Elife. 2018 Feb 26;7. pii: e31656. doi: 10.7554/eLife.31656.

15.06.2018: Seminar instead of JC: Mirjam Münch



13.06.2018: Manon
Two Ck1d transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.
Fustin JM1, Kojima R2, Itoh K2, Chang HY3, Shiqi Y2, Zhuang B2, Oji A4, Gibo S5, Narasimamurthy R6, Virshup D6, Kurosawa G7, Doi M2, Manabe I8, Ishihama Y3, Ikawa M4, Okamura H1.
Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):5980-5985. doi: 10.1073/pnas.1721371115. Epub 2018 May 21.

08.06.2018: canceled




01.06.2018: Bert
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock.
Wang Y1, Kuang Z1, Yu X1, Ruhn KA1, Kubo M2,3, Hooper LV4,5.
Science. 2017 Sep 1;357(6354):912-916. doi: 10.1126/science.aan0677.

25.05.2018: Anna
mTOR signaling regulates central and peripheral circadian clock function.
Ramanathan C1, Kathale ND1, Liu D2, Lee C3, Freeman DA1, Hogenesch JB4, Cao R2,5, Liu AC1,6.
PLoS Genet. 2018 May 11;14(5):e1007369. doi: 10.1371/journal.pgen.1007369. eCollection 2018 May.

18.05.2018: canceled




16.05.2018: Achim
paper of special interest



11.05.2018: Himmelfahrt Brückentag



04.05.2018: Christian
The choroid plexus is an important circadian clock component.
Myung J1,2,3,4,5, Schmal C6, Hong S7, Tsukizawa Y8, Rose P6, Zhang Y9, Holtzman MJ9, De Schutter E7, Herzel H10, Bordyugov G6, Takumi T11,12.
Nat Commun. 2018 Mar 14;9(1):1062. doi: 10.1038/s41467-018-03507-2.

27.04.2018: Abhi
A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa.
Zhou X1, Wang B1, Emerson JM1, Ringelberg CS1, Gerber SA1,2,3, Loros JJ2, Dunlap JC1.
PLoS Genet. 2018 Jan 19;14(1):e1007192. doi: 10.1371/journal.pgen.1007192. eCollection 2018 Jan.

20.04.2018: Teresa
FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.
Hirano A1, Braas D2, Fu YH3, Ptácek LJ4.
Cell Rep. 2017 Apr 11;19(2):255-266. doi: 10.1016/j.celrep.2017.03.041.

13.04.2018: canceled




06.04.2018: Easter break



30.03.2018: Karfreitag



23.03.2018: Carla
Circadian clock cryptochrome proteins regulate autoimmunity.
Cao Q1,2, Zhao X3, Bai J4,5, Gery S4, Sun H4, Lin DC4, Chen Q6, Chen Z2,7, Mack L8, Yang H9, Deng R10, Shi X4, Chong LW3, Cho H3, Xie J4, Li QZ11,12, Müschen M7, Atkins AR3, Liddle C13, Yu RT3, Alkan S14, Said JW15, Zheng Y8, Downes M16, Evans RM16,17, Koeffler HP4,9.
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. doi: 10.1073/pnas.1619119114. Epub 2017 Nov 6.

16.03.2018: Marta
Direct Midbrain Dopamine Input to the Suprachiasmatic Nucleus Accelerates Circadian Entrainment.
Grippo RM1, Purohit AM1, Zhang Q1, Zweifel LS2, Güler AD3.
Curr Biol. 2017 Aug 21;27(16):2465-2475.e3. doi: 10.1016/j.cub.2017.06.084. Epub 2017 Aug 3.

09.03.2019: Christian
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues.
Mure LS1, Le HD1, Benegiamo G1, Chang MW1,2, Rios L1, Jillani N3, Ngotho M3, Kariuki T3, Dkhissi-Benyahya O4, Cooper HM5, Panda S6.
Science. 2018 Feb 8. pii: eaao0318. doi: 10.1126/science.aao0318. [Epub ahead of print]

02.03.2018: Achim
paper of special interest



23.02.2018: Bharath
A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.
Bu Y1, Yoshida A1, Chitnis N1, Altman BJ2, Tameire F3, Oran A4, Gennaro V4, Armeson KE5, McMahon SB4, Wertheim GB6, Dang CV2, Ruggero D7, Koumenis C3, Fuchs SY8, Diehl JA9.
Nat Cell Biol. 2018 Jan;20(1):104-115. doi: 10.1038/s41556-017-0006-y. Epub 2017 Dec 11.

07.02.2018: Bert
The circadian clock in immune cells controls the magnitude of Leishmania parasite infection.
Kiessling S1,2, Dubeau-Laramée G1, Ohm H1, Labrecque N3, Olivier M4, Cermakian N5.
Sci Rep. 2017 Sep 7;7(1):10892. doi: 10.1038/s41598-017-11297-8.

31.01.2018: Anna
Involvement of posttranscriptional regulation of Clock in the emergence of circadian clock oscillation during mouse development.
Umemura Y1, Koike N1, Ohashi M1, Tsuchiya Y1, Meng QJ2, Minami Y1, Hara M1, Hisatomi M1, Yagita K3.
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7479-E7488. doi: 10.1073/pnas.1703170114. Epub 2017 Aug 21.

24.01.2018: Abhi
DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition.
Liu X1, Dang Y1, Matsu-Ura T2, He Y3, He Q4, Hong CI2, Liu Y5.
Mol Cell. 2017 Jul 20;67(2):203-213.e4. doi: 10.1016/j.molcel.2017.05.029. Epub 2017 Jun 22.

17.01.2018: Teresa
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Kriebs A1, Jordan SD1, Soto E1, Henriksson E1,2, Sandate CR1, Vaughan ME1, Chan AB1, Duglan D1, Papp SJ1, Huber AL1, Afetian ME1, Yu RT3, Zhao X3, Downes M3, Evans RM3,4,5, Lamia KA6,5.
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8776-8781. doi: 10.1073/pnas.1704955114. Epub 2017 Jul 27.

10.01.2018: Matthias
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A1, Xie W1,2, Agapov E1, Brown S1, Steinberg D1, Tidwell R1, Sajol G1, Schutz R1, Weaver R1, Yu H1, Castro M1, Bacharier LB3, Wang X2, Holtzman MJ1, Haspel JA1.
Mucosal Immunol. 2018 Jan;11(1):97-111. doi: 10.1038/mi.2017.24. Epub 2017 Apr 12.

27.12.2017/29.12.2017: Christmas break



20.12.2017: Achim
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.
Patke A1, Murphy PJ2, Onat OE3, Krieger AC4, Özçelik T3, Campbell SS2, Young MW5.
Cell. 2017 Apr 6;169(2):203-215.e13. doi: 10.1016/j.cell.2017.03.027.

15.12.2017: Marta (journal club instead of seminar)
Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Shinohara Y1, Koyama YM2, Ukai-Tadenuma M1, Hirokawa T3, Kikuchi M4, Yamada RG1, Ukai H1, Fujishima H1, Umehara T5, Tainaka K6, Ueda HR7.
Mol Cell. 2017 Sep 7;67(5):783-798.e20. doi: 10.1016/j.molcel.2017.08.009.

06.12.2017: Nicole
The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.
Aggarwal A1, Costa MJ1, Rivero-Gutiérrez B1, Ji L1, Morgan SL1, Feldman BJ2.
Cell Rep. 2017 Nov 28;21(9):2367-2375. doi: 10.1016/j.celrep.2017.11.004.

29.11.2017: Bharath
CYCLOPS reveals human transcriptional rhythms in health and disease.
Anafi RC1,2,3, Francey LJ4,5,6, Hogenesch JB4,5,6, Kim J7,8.
Proc Natl Acad Sci U S A. 2017 May 16;114(20):5312-5317. doi: 10.1073/pnas.1619320114. Epub 2017 Apr 24.

22.11.2017: Bert
Period2 3'-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Yoo SH1,2, Kojima S2, Shimomura K3, Koike N2,4, Buhr ED3, Furukawa T3, Ko CH3, Gloston G5, Ayoub C5, Nohara K5, Reyes BA6, Tsuchiya Y4, Yoo OJ7, Yagita K4, Lee C8, Chen Z5, Yamazaki S6, Green CB2, Takahashi JS9,10.
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8855-E8864. doi: 10.1073/pnas.1706611114. Epub 2017 Oct 2.

17.11.2017: Anna (journal club instead of seminar)
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing
Hoyle NP1, Seinkmane E2, Putker M2, Feeney KA2, Krogager TP2, Chesham JE2, Bray LK2, Thomas JM3, Dunn K4, Blaikley J5, O'Neill JS1.
Sci Transl Med. 2017 Nov 8;9(415). pii: eaal2774. doi: 10.1126/scitranslmed.aal2774.

08.11.2017: Lena
Fibroblast PER2 Circadian Rhythmicity Depends on Cell Density
Takako Noguchi,1 Lexie L. Wang,1 and David K. Welsh1,2,*
J Biol Rhythms. Author manuscript; available in PMC 2013 Sep 3. Published in final edited form as: J Biol Rhythms. 2013 Jun; 28(3): 183–192. doi: 10.1177/0748730413487494.

01.11.2017: Achim
CRISPR/Cas9-APEX-mediated proximity labeling enables discovery of proteins associated with a predefined genomic locus in living cells.
Samuel A. Myers, Jason Wright, Feng Zhang, Steven A. Carr
doi: https://doi.org/10.1101/159517 (This article is a preprint and has not been peer-reviewed).

25.10.2017: Christian
Macromolecular Assemblies of the Mammalian Circadian Clock.
Aryal RP1, Kwak PB1, Tamayo AG1, Gebert M1, Chiu PL2, Walz T3, Weitz CJ4.
Mol Cell. 2017 Sep 7;67(5):770-782.e6. doi: 10.1016/j.molcel.2017.07.017.

18.10.2017: Marta
Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage.
Wang H1, van Spyk E2, Liu Q3, Geyfman M2, Salmans ML2, Kumar V4, Ihler A3, Li N5, Takahashi JS6, Andersen B7.
Cell Rep. 2017 Aug 1;20(5):1061-1072. doi: 10.1016/j.celrep.2017.07.022.

11.10.2017: Nicole
Blood transcriptome based biomarkers for human circadian phase.
Laing EE1, Möller-Levet CS2, Poh N3, Santhi N4, Archer SN4, Dijk DJ4.
Elife. 2017 Feb 20;6. pii: e20214. doi: 10.7554/eLife.20214.

04.10.2017: Bharath
Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro.
Loizides-Mangold U1,2,3, Perrin L1,2,3, Vandereycken B4, Betts JA5, Walhin JP5, Templeman I5, Chanon S6, Weger BD7, Durand C6, Robert M8, Paz Montoya J9, Moniatte M9, Karagounis LG10,11, Johnston JD12, Gachon F7,13, Lefai E6, Riezman H14,15, Dibner C16,2,3.
Proc Natl Acad Sci U S A. 2017 Sep 25. pii: 201705821. doi: 10.1073/pnas.1705821114. [Epub ahead of print]

27.09.2017 : Christian
Paper of special interest


20.09.2017: Bert
Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice.
Zhao Y1, Liu M1, Chan XY1, Tan SY1, Subramaniam S1, Fan Y2, Loh E3, Chang KTE4, Tan TC5, Chen Q6.
Blood. 2017 Aug 29. pii: blood-2017-04-778779. doi: 10.1182/blood-2017-04-778779. [Epub ahead of print]

13.09.2017: Anna
Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice
Kamagata M1, Ikeda Y1, Sasaki H1, Hattori Y1, Yasuda S1, Iwami S1, Tsubosaka M1, Ishikawa R1, Todoh A1, Tamura K1, Tahara Y1, Shibata S1.
Chronobiol Int. 2017 Jul 13:1-16. doi: 10.1080/07420528.2017.1338716. [Epub ahead of print]

July - September 2017: Summer break



21.06.2017 : Anna




14.06.2017 : Christian




07.06.2017 : Thomas




02.06.2017 : no seminar




24.05.2017 : Sandra
Mammalian circadian period, but not phase and amplitude, is robust against redox and metabolic perturbations.
Putker M, Crosby P, Feeney KA, Hoyle NP, da Costa ASH, Gaude E, Frezza C, O'Neill JS.
Antioxid Redox Signal. 2017 May 15. doi: 10.1089/ars.2016.6911. [Epub ahead of print]

17.05.2017 : Achim
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
Sinturel F, Gerber A, Mauvoisin D, Wang J, Gatfield D, Stubblefield JJ, Green CB, Gachon F, Schibler U.
Cell. 2017 May 4;169(4):651-663.e14. doi: 10.1016/j.cell.2017.04.015.

10.05.2017 : Bert
Exercise contagion in a global social network.
Aral S, Nicolaides C.
Nat Commun. 2017 Apr 18;8:14753. doi: 10.1038/ncomms14753.

03.05.2017 : Sebastian
paper of special intrest



26.04.2017 : no seminar




19.04.2017 : Neta
Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats.
Thomas AP, Hoang J, Vongbunyong K, Nguyen A, Rakshit K, Matveyenko AV.
Endocrinology. 2016 Dec;157(12):4720-4731. Epub 2016 Sep 21.

12.04.2017 : Bharath
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Brancaccio M, Patton AP, Chesham JE, Maywood ES, Hastings MH.
Neuron. 2017 Mar 22;93(6):1420-1435.e5. doi: 10.1016/j.neuron.2017.02.030. Epub 2017 Mar 9.

05.04.2017 : Nicole
Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
Kuintzle RC, Chow ES, Westby TN, Gvakharia BO, Giebultowicz JM, Hendrix DA.
Nat Commun. 2017 Feb 21;8:14529. doi: 10.1038/ncomms14529.

29.03.2017 : Anna
Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation
Yu Tahara, Yuta Takatsu, Takuya Shiraishi, Yosuke Kikuchi, Mayu Yamazaki, Hiroaki Motohashi, Aya Muto, Hiroyuki Sasaki, Atsushi Haraguchi, Daisuke Kuriki, Takahiro J Nakamura & Shigenobu Shibata
npj Aging and Mechanisms of Disease 3, Article number: 16030 (2017) doi:10.1038/npjamd.2016.30

22.03.2017 : Achim
How jet lag impairs Major League Baseball performance.
Song A, Severini T, Allada R.
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1407-1412. doi: 10.1073/pnas.1608847114.

15.03.2017 : Thomas
Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Michael AK, Fribourgh JL, Chelliah Y, Sandate CR, Hura GL, Schneidman-Duhovny D, Tripathi SM, Takahashi JS, Partch CL.
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1560-1565. doi: 10.1073/pnas.1615310114.

08.03.2017 : Christian
Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep.
Gizowski C, Zaelzer C & Bourque CW.
Nature 2016 537, 685–688.

01.03.2017 : Sandra
Mammalian Period represses and de-represses transcription by displacing CLOCK -BMAL1 from promoters in a Cryptochrome-dependent manner.
Chiou Y, Yang Y, Rashid N, Ye R, Selby CP & Sancar A
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6072-E6079. Epub 2016 Sep 29.

22.02.2017 : Bert
Discrete functions of nuclear receptor Rev-erba couple metabolism to the clock.
Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ & Lazar MA.
Science. 2015, 348, 1488–92.

15.02.2017 : Neta
Circadian Clock Interaction with HIF1a Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle.
Peek CB, Levine DC, Cedernaes J, Taguchi A, Kobayashi Y, Tsai SJ, Bonar NA, McNulty MR, Ramsey KM, Bass J.
Cell Metab. 2017 Jan 10;25(1):86-92. doi: 10.1016/j.cmet.2016.09.010. Epub 2016 Oct 20.

08.02.2017 : Nicole
Cellular mechano-environment regulates the mammary circadian clock.
Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, Meng QJ.
Nat Commun. 2017 Jan 30;8:14287. doi: 10.1038/ncomms14287.

01.02.2017 : Bharath
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology.
Robles MS, Humphrey SJ, Mann M.
Cell Metab. 2017 Jan 10;25(1):118-127. doi: 10.1016/j.cmet.2016.10.004. Epub 2016 Nov 3.

25.01.2017 : Anna
Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.
Druzd D, Matveeva O, Ince L, Harrison U, He W1, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C.
Immunity. 2017 Jan 17;46(1):120-132. doi: 10.1016/j.immuni.2016.12.011. Epub 2017 Jan 10.

18.01.2017 : Achim
Paper of special interest



11.01.2017 : Christian
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC.
Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16.

04.01.2017 : Thomas
Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.
Ode KL, Ukai H, Susaki EA, Narumi R, Matsumoto K, Hara J, Koide N, Abe T, Kanemaki MT, Kiyonari H, Ueda HR.
Mol Cell. 2016 Dec 10. pii: S1097-2765(16)30758-4. doi: 10.1016/j.molcel.2016.11.022. [Epub ahead of print]

21.12.2016 : Sandra
Melatonin promotes circadian rhythm-induced proliferation through interaction of Clock/HDAC3/c-Myc in mice adipose tissue.
Liu Z, Gan L, Luo D, Sun C.
J Pineal Res. 2016 Dec 17. doi: 10.1111/jpi.12383. [Epub ahead of print]

14.12.2016 : Sebastian F
no seminar



07.12.2016 : Achim
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations.
Thaiss CA, Levy M, Korem T, Dohnalová L, Shapiro H, Jaitin DA, David E1, Winter DR1, Gury-BenAri M1, Tatirovsky E1, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E.
Cell. 2016 Dec 1;167(6):1495-1510.e12. doi: 10.1016/j.cell.2016.11.003.

30.11.2016 : Bert
Dissociation of Molecular and Endocrine Circadian Rhythms in Male Mice Lacking Bmal1 in the Adrenal Cortex.
Dumbell R, Leliavski A, Matveeva O, Blaum C, Tsang AH, Oster H.
Endocrinology. 2016 Nov;157(11):4222-4233. Epub 2016 Oct 3.

23.11.2016 : Neta
Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock.
Dang F, Sun X, Ma X, Wu R, Zhang D, Chen Y, Xu Q, Wu Y, Liu Y.
Nat Commun. 2016 Aug 31;7:12696. doi: 10.1038/ncomms12696.

16.11.2016 : Grisha
Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics.
Roberts L, Leise TL, Welsh DK, Holmes TC.
J Biol Rhythms. 2016 Aug;31(4):337-51. doi: 10.1177/0748730416649550. Epub 2016 May 24.

09.11.2016 : Elyzana
Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes.
Suzuki K, Hayano Y, Nakai A, Furuta F, Noda MJ Exp Med. 2016 Nov 14;213(12):2567-2574. Epub 2016 Oct 31.


02.11.2016 : Nicole
ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system.
Hughey JJ, Hastie T, Butte AJ.
Nucleic Acids Res. 2016 May 5;44(8):e80. doi: 10.1093/nar/gkw030. Epub 2016 Jan 26.

26.10.2016 : Sebastian
Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp.
Gotic I, Omidi S, Fleury-Olela F, Molina N, Naef F, Schibler U.
Genes Dev. 2016 Sep 1;30(17):2005-17. doi: 10.1101/gad.287094.116. Epub 2016 Sep 15.

19.10.2016 : Sarah (Ag Westermark)
In-depth Characterization of Firefly Luciferase as a Reporter of Circadian Gene Expression in Mammalian Cells
Kevin A. Feeney, Marrit Putker, Marco Brancaccio, and John S. O’Neill
J Biol Rhythms October 10, 2016

12.10.2016 : Thomas
paper of special interest



05.10.2016 : Sandra
Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2.
Smyllie NJ, Pilorz V, Boyd J, Meng QJ, Saer B, Chesham JE, Maywood ES, Krogager TP, Spiller DG, Boot-Handford R, White MR, Hastings MH, Loudon AS.
Curr Biol. 2016 Jul 25;26(14):1880-6. doi: 10.1016/j.cub.2016.05.018. Epub 2016 Jun 30.

28.09.2016 : Sebastian F
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10085-90. doi: 10.1073/pnas.1601895113. Epub 2016 Aug 15.

21.09.2016 : Achim
The Pentose Phosphate Pathway Regulates the Circadian Clock.
Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O'Neill JS, Reddy AB.
Cell Metab. 2016 Sep 13;24(3):462-73. doi: 10.1016/j.cmet.2016.07.024. Epub 2016 Aug 18.

06.09.2016 : Bert
Circadian regulation of sunflower heliotropism, floral orientation, and pollinator visits.
Atamian HS, Creux NM, Brown EA, Garner AG, Blackman BK, Harmer SL.
Science. 2016 Aug 5;353(6299):587-90. doi: 10.1126/science.aaf9793.

30.08.2016 : no seminar



23.08.2016 : Neta
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERB? Degradation
Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.
Cell. 2016 Jun 16;165(7):1644-57. doi: 10.1016/j.cell.2016.05.012. Epub 2016 May 26.

26.07.2016 - 16.08.16: Summer Break



19.07.2016 : no seminar




12.07.2016 : Elyzana Projekt-Seminar




05.07.2016 : Grisha




28.06.2016 : Elyzana
Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.
Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P.
Cell. 2016 May 5;165(4):896-909. doi: 10.1016/j.cell.2016.04.039.

21.06.2016 : Achim
Update SRBR



14.06.2016 : Bharath
Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression.
Xu Y, Guo W, Li P, Zhang Y, Zhao M, Fan Z, Zhao Z, Yan J.
PLoS Genet. 2016 May 2;12(5):e1005992. doi: 10.1371/journal.pgen.1005992. eCollection 2016.

07.06.2016 : Sebastian J
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression.
Chen X, Rosbash M.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2965-72. doi: 10.1073/pnas.1605837113. Epub 2016 May 9.

31.05.2016 : AG Westermark




24.05.2016 : Thomas
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.
He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z.
Cell Metab. 2016 Apr 12;23(4):610-21. doi: 10.1016/j.cmet.2016.03.007.

17.05.2016 : Sandra
Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms.
Patel SA, Velingkaar N, Makwana K, Chaudhari A, Kondratov R.
Sci Rep. 2016 May 12;6:25970. doi: 10.1038/srep25970.

10.05.2016 : no seminar




03.05.2016 : Sebastian F
The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function.
Hemmers S, Rudensky AY.
Cell Rep. 2015 Jun 9;11(9):1339-49. doi: 10.1016/j.celrep.2015.04.058. Epub 2015 May 21.

26.04.2016 : Anna
TH17 cell differentiation is regulated by the circadian clock.
Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.
Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.

19.04.2016 : Achim
Daily magnesium fluxes regulate cellular timekeeping and energy balance.
Feeney KA, Hansen LL, Putker M, Olivares-Yañez C, Day J, Eades LJ, Larrondo LF, Hoyle NP, O'Neill JS, van Ooijen G.
Nature. 2016 Apr 13. doi: 10.1038/nature17407. [Epub ahead of print]

12.04.2016 : Silke
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen MC, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL.
Cell. 2016 Apr 7;165(2):303-16. doi: 10.1016/j.cell.2016.03.015.

05.04.2016 : Bert
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait.
Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptá?ek LJ, Fu YH.
Proc Natl Acad Sci U S A. 2016 Feb 22. pii: 201600039. [Epub ahead of print]

24.03.2016 : Ute
Temporally chimeric mice reveal flexibility of circadian period-setting in the suprachiasmatic nucleus.
Smyllie NJ, Chesham JE, Hamnett R, Maywood ES, Hastings MH.
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3657-62. doi: 10.1073/pnas.1511351113. Epub 2016 Mar 10.

22.03.2016 : no seminar




17.03.2016 : Neta
Oxyntomodulin regulates resetting of the liver circadian clock by food
Landgraf D, Tsang AH, Leliavski A, Koch CE, Barclay JL, Drucker DJ, Oster H.
Elife. 2015 Mar 30;4:e06253. doi: 10.7554/eLife.06253.

08.03.2016 : Elyzana
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock.
Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A.
J Allergy Clin Immunol. 2015 Nov 7. pii: S0091-6749(15)01370-6. doi: 10.1016/j.jaci.2015.08.052. [Epub ahead of print]

01.03.2016 : Bharath
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA.
Sci Transl Med. 2016 Feb 3;8(324):324ra16. doi: 10.1126/scitranslmed.aad3305. Epub 2016 Feb 3.

23.02.2016 : Sebastian
Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus.
Xu H, Gustafson CL, Sammons PJ, Khan SK, Parsley NC, Ramanathan C, Lee HW, Liu AC, Partch CL.
Nat Struct Mol Biol. 2015 Jun;22(6):476-84. doi: 10.1038/nsmb.3018. Epub 2015 May 11.

16.02.2016 : Veronika
Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans.
Cuesta M, Boudreau P, Dubeau-Laramée G, Cermakian N, Boivin DB.
J Immunol. 2016 Feb 12. pii: 1502422. [Epub ahead of print]

09.02.2016 : AG Westermark
Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos
Cela O, Scrima R, Pazienza V, Merla G, Benegiamo G, Augello B, Fugetto S, Menga M, Rubino R, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N.
Biochim Biophys Acta. 2015 Dec 28;1863(4):596-606. doi: 10.1016/j.bbamcr.2015.12.018. [Epub ahead of print]

02.02.2016 : Charlotte
Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks.
Tataroglu O, Zhao X, Busza A, Ling J, O'Neill JS, Emery P.
Cell. 2015 Nov 19;163(5):1214-24. doi: 10.1016/j.cell.2015.10.031.

26.01.2016 : Achim
Pancreatic ? cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, Bass J.
Science. 2015 Nov 6;350(6261):aac4250. doi: 10.1126/science.aac4250.

19.01.2016 : Achim
Update on CRISPR/CAS9



12.01.2016 : Achim
How to write a paper.



05.01.2016 : Silke
Natural selection against a circadian clock gene mutation in mice.
Spoelstra K, Wikelski M, Daan S, Loudon AS, Hau M.
Proc Natl Acad Sci U S A. 2015 Dec 29. pii: 201516442. [Epub ahead of print]