achim kramer lab

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22.12.2015 : no seminar




15.12.2015 : Sebastian
A tunable artificial circadian clock in clock-defective mice.
D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C.
Nat Commun. 2015 Nov 30;6:8587. doi: 10.1038/ncomms9587.

08.12.2015 : Bert
Temperature compensation and temperature sensation in the circadian clock.
Kidd PB, Young MW, Siggia ED.
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6284-92. doi: 10.1073/pnas.1511215112. Epub 2015 Nov 2.

01.12.2015 : Achim
Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
Chen C, Buhl E, Xu M, Croset V, Rees JS, Lilley KS, Benton R, Hodge JJ, Stanewsky R.
Nature. 2015 Nov 26;527(7579):516-20. doi: 10.1038/nature16148. Epub 2015 Nov 1

24.11.2015 : Neta
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.
Zwighaft Z, Aviram R, Shalev M, Rousso-Noori L, Kraut-Cohen J, Golik M, Brandis A, Reinke H, Aharoni A, Kahana C, Asher G.
Cell Metab. 2015 Nov 3;22(5):874-85. doi: 10.1016/j.cmet.2015.09.011. Epub 2015 Oct 8.

17.11.2015 : Elyzana
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.
Cell Metab. 2015 Sep 16. pii: S1550-4131(15)00460-X. doi: 10.1016/j.cmet.2015.09.003. [Epub ahead of print]

10.11.2015 : Bharath
PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription.
Zhao H, Sifakis EG, Sumida N, Millán-Ariño L, Scholz BA, Svensson JP, Chen X, Ronnegren AL, Mallet de Lima CD, Varnoosfaderani FS, Shi C, Loseva O, Yammine S, Israelsson M, Rathje LS, Németi B, Fredlund E, Helleday T, Imreh MP, Göndör A.
Mol Cell. 2015 Sep 17;59(6):984-97. doi: 10.1016/j.molcel.2015.07.019. Epub 2015 Aug 27.

05.11.2015 : AG Westermark
Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames.
Janich P, Arpat AB, Castelo-Szekely V, Lopes M, Gatfield D.
Genome Res. 2015 Dec;25(12):1848-59. doi: 10.1101/gr.195404.115. Epub 2015 Oct 20.

27.10.2015 : Charlotte
Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N.
Nat Neurosci. 2015 Jun;18(6):855-62. doi: 10.1038/nn.4010. Epub 2015 Apr 27.

20.10.2015 : Achim
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period.
Zhou M, Kim JK, Eng GW, Forger DB, Virshup DM.
Mol Cell. 2015 Oct 1;60(1):77-88. doi: 10.1016/j.molcel.2015.08.022.

13.10.2015 : Thomas
Ubiquitin ligase Siah2 regulates RevErb? degradation and the mammalian circadian clock.
DeBruyne JP, Baggs JE, Sato TK, Hogenesch JB.
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12420-5. doi: 10.1073/pnas.1501204112. Epub 2015 Sep 21.

06.10.2015 : Silke
Circadian Oscillation of Sulfiredoxin in the Mitochondria.
Kil IS, Ryu KW, Lee SK, Kim JY, Chu SY, Kim JH, Park S, Rhee SG.
Mol Cell. 2015 Aug 20;59(4):651-63. doi: 10.1016/j.molcel.2015.06.031. Epub 2015 Jul 30.

29.09.2015 : Bert
Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.
Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ.
Nat Struct Mol Biol. 2015 Oct;22(10):759-66. doi: 10.1038/nsmb.3076. Epub 2015 Aug 31.

22.09.2015 : Elyzana
Redox rhythm reinforces the circadian clock to gate immune response.
Zhou M, Wang W, Karapetyan S, Mwimba M, Marqués J, Buchler NE, Dong X.
Nature. 2015 Jul 23;523(7561):472-6. doi: 10.1038/nature14449. Epub 2015 Jun 22.

15.09.2015 : no seminar




08.09.2015 : Ute
GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time.
Myung J, Hong S, DeWoskin D, De Schutter E, Forger DB, Takumi T.
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3920-9. doi: 10.1073/pnas.1421200112. Epub 2015 Jun 30.

01.09.2015 : no seminar




25.08.2015 : Neta
Circadian Dysfunction Induces Leptin Resistance in Mice.
Kettner NM, Mayo SA, Hua J, Lee C, Moore DD, Fu L.
Cell Metab. 2015 Sep 1;22(3):448-59. doi: 10.1016/j.cmet.2015.06.005. Epub 2015 Jul 9.

18.08.2015 : Sandra
GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins.
Mehta N, Cheng AH, Chiang CK, Mendoza-Viveros L, Ling HH, Patel A, Xu B, Figeys D, Cheng HY.
Cell Rep. 2015 Aug 25;12(8):1272-88. doi: 10.1016/j.celrep.2015.07.037. Epub 2015 Aug 13.

11.08.2015 : Bharath
The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.
Parsons MJ, Brancaccio M, Sethi S, Maywood ES, Satija R, Edwards JK, Jagannath A, Couch Y, Finelli MJ, Smyllie NJ, Esapa C, Butler R, Barnard AR, Chesham JE, Saito S, Joynson G, Wells S, Foster RG, Oliver PL, Simon MM, Mallon AM, Hastings MH, Nolan PM.
Cell. 2015 Jul 30;162(3):607-21. doi: 10.1016/j.cell.2015.06.060.

04.08.2015 : Sebastian
Discrete functions of nuclear receptor Rev-erb? couple metabolism to the clock.
Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA.
Science. 2015 Jun 26;348(6242):1488-92. doi: 10.1126/science.aab3021. Epub 2015 Jun 4.

28.07.2015 : AG Westermark
Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.
Larrondo LF, Olivares-Yañez C, Baker CL, Loros JJ, Dunlap JC.
Science. 2015 Jan 30;347(6221):1257277. doi: 10.1126/science.1257277.

21.07.2015 : no seminar




14.07.2015 : Thomas
Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells.
Hoffmann J, Symul L, Shostak A, Fischer T, Naef F, Brunner M.
PLoS One. 2014 Jul 9;9(7):e102238. doi: 10.1371/journal.pone.0102238. eCollection 2014.

07.07.2015 : no seminar




30.06.2015 : no seminar




23.06.2015 : Silke
Transplantability of a circadian clock to a noncircadian organism
Anna H. Chen, David Lubkowicz, Vivian Yeong, Roger L. Chang and Pamela A. Silver
Science Advances. 2015 June 12; 1(5) e1500358 DOI: 10.1126/sciadv.1500358

16.06.2015 : Bert
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation.
Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M.
Cell. 2015 May 21;161(5):1138-51. doi: 10.1016/j.cell.2015.04.002. Epub 2015 May 14.

09.06.2015 : Ute
Colour as a signal for entraining the mammalian circadian clock.
Walmsley L, Hanna L, Mouland J, Martial F, West A, Smedley AR, Bechtold DA, Webb AR, Lucas RJ, Brown TM.
PLoS Biol. 2015 Apr 17;13(4):e1002127. doi: 10.1371/journal.pbio.1002127. eCollection 2015.

02.06.2015 : Neta
Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A Jr, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y.
Endocrinology. 2015 Jun;156(6):2114-23. doi: 10.1210/en.2014-1922. Epub 2015 Mar 25.

26.05.2015 : Elyzana
Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms.
Causton HC, Feeney KA, Ziegler CA, O'Neill JS.
Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms.

19.05.2015 :no seminar




12.05.2015 : Sandra
Method of the year 2014 (Nature)



05.05.2015 : Bharath
Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.
Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M.
Neuron. 2015 Mar 4;85(5):1086-102. doi: 10.1016/j.neuron.2015.02.006.

28.04.2015 : Sebastian
Drosophila TIM binds importin ?1, and acts as an adapter to transport PER to the nucleus.
Jang AR, Moravcevic K, Saez L, Young MW, Sehgal A.
PLoS Genet. 2015 Feb 12;11(2):e1004974. doi: 10.1371/journal.pgen.1004974. eCollection 2015.

21.04.2015 : AG Westermark
Sustained activation of GABAA receptors in the suprachiasmatic nucleus mediates light-induced phase delays of the circadian clock: a novel function of ionotropic receptors.
Hummer DL, Ehlen JC, Larkin TE 2nd, McNeill JK 4th, Pamplin JR 2nd, Walker CA, Walker PV 2nd, Dhanraj DR, Albers HE.
Eur J Neurosci. 2015 Apr 11. doi: 10.1111/ejn.12918. [Epub ahead of print]

14.04.15 at 9:00 AM:Lea Abschlussseminar




07.04.2015 : no seminar




31.03.2015 : no seminar




24.03.2015 : no seminar




17.03.2015 : Thomas
NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Aguilar-Arnal L, Katada S, Orozco-Solis R, Sassone-Corsi P.
Nat Struct Mol Biol. 2015 Mar 9. doi: 10.1038/nsmb.2990. [Epub ahead of print]

10.03.2015 : no seminar




03.03.2015 : Achim
paper of special interest



24.02.2015 : Silke
Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock.
Bee L, Marini S, Pontarin G, Ferraro P, Costa R, Albrecht U, Celotti L.
Nucleic Acids Res. 2015 Feb 27;43(4):2126-37. doi: 10.1093/nar/gkv081. Epub 2015 Feb 6.

17.02.2015 : Ute
Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.
Jones JR, Tackenberg MC, McMahon DG.
Nat Neurosci. 2015 Mar;18(3):373-5. doi: 10.1038/nn.3937. Epub 2015 Feb 2.

10.02.2015 : Bert
paper of special interest



03.02.2015 : Bharath
Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo.
Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA.
Cell. 2014 Nov 20;159(5):1140-52. doi: 10.1016/j.cell.2014.10.022.

27.01.2015 : Neta
Glucagon-CREB/CRTC2 Signaling Cascade Regulates Hepatic BMAL1 Protein.
Sun X, Dang F, Zhang D, Yuan Y, Zhang C, Wu Y, Wang Y, Liu Y.
J Biol Chem. 2015 Jan 23;290(4):2189-97. doi: 10.1074/jbc.M114.612358. Epub 2014 Dec 5.

20.01.2015 : Sandra
The zebrafish Period2 protein positively regulates the circadian clock through mediation of RAR-related orphan receptor alpha (Ror?).
Wang M1, Zhong Z1, Zhong Y1, Zhang W1, Wang H2.
J Biol Chem. 2014 Dec 28. pii: jbc.M114.605022. [Epub ahead of print]

13.01.2015 : Elyzana
Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase.
Johnson BP1, Walisser JA1, Liu Y1, Shen AL1, McDearmon EL2, Moran SM1, McIntosh BE1, Vollrath AL1, Schook AC2, Takahashi JS3, Bradfield CA4.
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18757-62. doi: 10.1073/pnas.1421708111. Epub 2014 Dec 15.

06.01.2015 : Bharath
Lhx1 maintains synchrony among circadian oscillator neurons of the SCN.
Hatori M1, Gill S2, Mure LS2, Goulding M3, O'Leary DD3, Panda S4.
Elife. 2014 Jul 17;3:e03357. doi: 10.7554/eLife.03357.