achim kramer lab

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31.12.2013 : no seminar




24.12.2013 : no seminar




10.12.2013 : Sandra
The nuclear receptor Rev-erb? controls circadian thermogenic plasticity.
Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA.
Nature. 2013 Nov 21;503(7476):410-3. doi: 10.1038/nature12642. Epub 2013 Oct 27.

17.12.2013 : no seminar




03.12.2013 : Bharath
Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.
Yamaguchi Y, Suzuki T, Mizoro Y, Kori H, Okada K, Chen Y, Fustin JM, Yamazaki F, Mizuguchi N, Zhang J, Dong X, Tsujimoto G, Okuno Y, Doi M, Okamura H.
Science. 2013 Oct 4;342(6154):85-90. doi: 10.1126/science.1238599.

26.11.2013 : Sebastian
TH17 cell differentiation is regulated by the circadian clock.
Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV.
Science. 2013 Nov 8;342(6159):727-30. doi: 10.1126/science.1243884.

19.11.2013 : AG Westermark
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock.
Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H.
Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.

12.11.2013 : Thomas
Phosphorylation of the Cryptochrome 1 C-terminal tail regulates circadian period length.
Gao P, Yoo SH, Lee KJ, Rosensweig C, Takahashi JS, Chen BP, Green CB.
J Biol Chem. 2013 Oct 24. [Epub ahead of print]

05.11.2013 : Veronika
A neuropeptide speeds circadian entrainment by reducing intercellular synchrony.
An S, Harang R, Meeker K, Granados-Fuentes D, Tsai CA, Mazuski C, Kim J, Doyle FJ 3rd, Petzold LR, Herzog ED
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4355-61. doi: 10.1073/pnas.1307088110. Epub 2013 Oct 28.

29.10.2013 : Achim
miRNAs Are Required for Generating a Time Delay Critical for the Circadian Oscillator.
Chen R, D'Alessandro M, Lee C.
Curr Biol. 2013 Oct 21;23(20):1959-68. doi: 10.1016/j.cub.2013.08.005. Epub 2013 Oct 3.

22.10.2013 : no seminar




15.10.2013 : Silke
A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
Lande-Diner L, Boyault C, Kim JY, Weitz CJ.
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16021-6. doi: 10.1073/pnas.1305980110. Epub 2013 Sep 16.

08.10.2013 : Bert
Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes.
Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A.
Science. 2013 Sep 27;341(6153):1483-8. doi: 10.1126/science.1240636. Epub 2013 Aug 22.

01.10.2013 : no seminar




24.09.2013 : no seminar




17.09.2013 : Neta
Real-time monitoring in three-dimensional hepatocytes reveals that insulin acts as a synchronizer for liver clock.
Yamajuku D, Inagaki T, Haruma T, Okubo S, Kataoka Y, Kobayashi S, Ikegami K, Laurent T, Kojima T, Noutomi K, Hashimoto S, Oda H.
Sci Rep. 2012;2:439. doi: 10.1038/srep00439. Epub 2012 Jun 1.

10.09.2013 : Sandra
The nuclear localization of glycogen synthase kinase 3? is required its putative PY-nuclear localization sequences.
Shin SH, Lee EJ, Chun J, Hyun S, Kim YI, Kang SS.
Mol Cells. 2012 Oct;34(4):375-82. doi: 10.1007/s10059-012-0167-2. Epub 2012 Oct 18.

03.09.2013 : Bharath
Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling.
Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N.
Neuron. 2013 Aug 21;79(4):712-24. doi: 10.1016/j.neuron.2013.06.026.

27.08.2013 : Sebastian
Paper of special interest



20.08.2013 : AG Westermark
Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A.
Cell. 2013 May 23;153(5):1025-35. doi: 10.1016/j.cell.2013.04.040.

13.08.2013 : Achim
Paper of special interest



06.08.2013 : Thomas
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging.
Chang HC, Guarente L.
Cell. 2013 Jun 20;153(7):1448-60. doi: 10.1016/j.cell.2013.05.027.

30.07.2013 : no seminar




23.07.2013 : no seminar




16.07.2013 : no seminar




09.07.2013 : Veronika
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.
Kondratov RV, Chernov MV, Kondratova AA, Gorbacheva VY, Gudkov AV, Antoch MP.
Genes Dev. 2003 Aug 1;17(15):1921-32.

02.07.2013 : Achimhttp://www.ncbi.nlm.nih.gov/pubmed/22927403
Human blood metabolite timetable indicates internal body time.
Kasukawa T, Sugimoto M, Hida A, Minami Y, Mori M, Honma S, Honma K, Mishima K, Soga T, Ueda HR.
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15036-41. doi: 10.1073/pnas.1207768109. Epub 2012 Aug 27.

25.06.2013 : Katja
Rhythmic control of the ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 in malignant cells
Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.
Cancer Res. 2013 Apr 15;73(8):2639-49. doi: 10.1158/0008-5472.CAN-12-2492. Epub 2013 Apr 11.

18.06.2013 : Manjana
A role for Drosophila ATX2 in activation of PER translation and circadian behavior.
Zhang Y, Ling J, Yuan C, Dubruille R, Emery P.
Science. 2013 May 17;340(6134):879-82. doi: 10.1126/science.1234746.

11.06.2013 : Bert
Circadian clock regulates the host response to Salmonella.
Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P.
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9897-902. doi: 10.1073/pnas.1120636110. Epub 2013 May 28.

04.06.2013 : Silke
MicroRNA-185 oscillation controls circadian amplitude of mouse CRYPTOCHROME1 via translational regulation.
Lee KH, Kim SH, Lee HR, Kim W, Kim DY, Shin JC, Yoo SH, Kim KT.
Mol Biol Cell. 2013 May 22. [Epub ahead of print]

28.05.2013 : Neta
Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA.
Nat Med. 2012 Dec;18(12):1768-77. doi: 10.1038/nm.2979. Epub 2012 Nov 11.

21.05.2013 : no seminar




14.5.2013 : Sandra
Distinct and Separable Roles for Endogenous CRY1 and CRY2 within the Circadian Molecular Clockwork of the Suprachiasmatic Nucleus, as Revealed by the Fbxl3Afh Mutation.
Anand SN, Maywood ES, Chesham JE, Joynson G, Banks GT, Hastings MH, Nolan PM.
J Neurosci. 2013 Apr 24;33(17):7145-53. doi: 10.1523/JNEUROSCI.4950-12.2013.

07.05.2013 : Achim
paper of special interest



30.04.2013 : Bharath
on-optimal codon usage affects expression, structure and function of clock protein FRQ.
Zhou M, Guo J, Cha J, Chae M, Chen S, Barral JM, Sachs MS, Liu Y.
Nature. 2013 Mar 7;495(7439):111-5. doi: 10.1038/nature11833. Epub 2013 Feb 17.

23.04.2013 : Veronika
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS.
Elife. 2013 Apr 9;2:e00426. doi: 10.7554/eLife.00426. Print 2013.

16.04.2013 : AG Westermark
Two antagonistic clock-regulated histidine kinases time the activation of circadian gene expression.
Gutu A, O'Shea EK.
Mol Cell. 2013 Apr 25;50(2):288-94. doi: 10.1016/j.molcel.2013.02.022. Epub 2013 Mar 28.

12.04.2013 : Sebastian
paper of special interest



02.04.2013 : Katja
Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
Stratmann M, Suter DM, Molina N, Naef F, Schibler U.
Mol Cell. 2012 Oct 26;48(2):277-87. doi: 10.1016/j.molcel.2012.08.012. Epub 2012 Sep 13.

26.03.2013 : Achim
paper of special interest



19.03.2013 : Agnes
Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm.
Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS.
Cell. 2013 Feb 28;152(5):1091-105. doi: 10.1016/j.cell.2013.01.055.

12.03.2013 : Manjana
FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes.
Hirano A, Yumimoto K, Tsunematsu R, Matsumoto M, Oyama M, Kozuka-Hata H, Nakagawa T, Lanjakornsiripan D, Nakayama KI, Fukada Y.
Cell. 2013 Feb 28;152(5):1106-18. doi: 10.1016/j.cell.2013.01.054.

05.03.2013 : Silke
Circadian Disruption Leads to Insulin Resistance and Obesity.
Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH.
Curr Biol. 2013 Feb 19. pii: S0960-9822(13)00083-3. doi: 10.1016/j.cub.2013.01.048. [Epub ahead of print]

26.02.2013 : Bert
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS.
Immunity. 2012 Aug 24;37(2):290-301. doi: 10.1016/j.immuni.2012.05.021. Epub 2012 Aug 2.

22.02.2013 (11 a.m.; Sky Room) : Charo Robles (AG Matthias Mann, MPI of Biochemistry)

“In-Vivo Quantitative Proteomics: Post-Transcriptional Mechanisms are a Key to the Circadian Regulation of Liver Metabolism“


19.02.2013 : Jeannine
Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity.
Gerber A, Esnault C, Aubert G, Treisman R, Pralong F, Schibler U.
Cell. 2013 Jan 31;152(3):492-503. doi: 10.1016/j.cell.2012.12.027.

07.02.2013 : Sandra
FLASH assembly of TALENs for high-throughput genome editing.
Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK.
Nat Biotechnol. 2012 May;30(5):460-5. doi: 10.1038/nbt.2170.

05.02.2013 : no seminar




29.01.2013 : Bharath
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation.
Menet JS, Rodriguez J, Abruzzi KC, Rosbash M.
elife. 2012;1:e00011. doi: 10.7554/eLife.00011. Epub 2012 Nov 13.

22.01.2013 : AG Westermarkb (Sarah)
Nascent-Seq analysis of Drosophila cycling gene expression.
Rodriguez J, Tang CH, Khodor YL, Vodala S, Menet JS, Rosbash M.
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):E275-84. doi: 10.1073/pnas.1219969110. Epub 2013 Jan 7.

15.01.2013 : Veronika
Feature Article: NONO couples the circadian clock to the cell cycle.
Kowalska E, Ripperger JA, Hoegger DC, Bruegger P, Buch T, Birchler T, Mueller A, Albrecht U, Contaldo C, Brown SA.
Proc Natl Acad Sci U S A. 2012 Dec 24. [Epub ahead of print]

08.01.2013 : Katja
Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression.
Kojima S, Sher-Chen EL, Green CB.
Genes Dev. 2012 Dec 15;26(24):2724-36. doi: 10.1101/gad.208306.112.

01.01.2013 : no seminar