Our group is engaged in understanding the molecular basics of the circadian clockwork in mammals and their impact on physiological and behavioral processes.
We are studying the regulation of intracellular processes which generate circadian oscillations with biochemical, genetic, molecular- and cell-biological methods.
One focus of the lab is to characterize post-transcriptional and post-translational mechanisms essential for the dynamics of circadian oscillations and thereby for physiology and behavior
(funding by Deutsche Forschungsgemeinschaft SFB740.
We have performed a genome-wide RNAi-based screen and identified many up to now unknown genes important for circadian rhythm generation. Many projects in the lab are centered on newly
discovered putative clock genes and the investigation of their mechanistic action within the molecular clockwork.
We also have projects together with clinical chronobiologists. For example, within the BMBF-funded collaborative project OLIVE), we study peripheral clocks in humans
on a transcriptome-wide level and their predictive power for chronobiological disturbances.
Together with theoretical biologists and mathematicians we develop theoretical concepts for the generation of molecular oscillations and synchronization of oscillating systems.
Another topic of our research is to study the function of circadian clocks for physiology in the brain and peripheral organs, e.g. the role of the circadian clock in the immune system.