achim kramer lab

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2017

El-Athman R, Genov NN, Mazuch J, Zhang K, Yu Y, Fuhr L, Abreu M, Li Y, Wallach T, Kramer A, Schmitt CA, Relógio A.
The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
PLoS Biology. 2017, in press[]

Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA,...
Guidelines for Genome-Scale Analysis of Biological Rhythms.
J Biol Rhythms. 2017 Nov 1:748730417728663. doi: 10.1177/0748730417728663. [Epub ahead of print][PubMed Link]

Gaspar L, Howald C, Popadin K, Maier B, Mauvoisin D, Moriggi E, Gutierrez-Arcelus M, Falconnet E, Borel C, Kunz D, Kramer A, Gachon F, Dermitzakis ET, Antonarakis SE, Brown SA.
The genomic landscape of human cellular circadian variation points to a novel role for the signalosome.
Elife. 2017 Sep 4;6. pii: e24994. doi: 10.7554/eLife.24994.[PubMed Link]

Thurley K, Herbst C, Wesener F, Koller B, Wallach T, Maier B, Kramer A, Westermark PO.
Principles for circadian orchestration of metabolic pathways.
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1572-1577. doi: 10.1073/pnas.1613103114.[PubMed Link]

2016

Pett JP, Korenčič A, Wesener F, Kramer A, Herzel H.
Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.
PLoS Comput Biol. 2016 Dec 12;12(12):e1005266. doi: 10.1371/journal.pcbi.1005266. [Epub ahead of print][PubMed Link]

Klemz R, Reischl S, Wallach T, Witte N, Jürchott K, Klemz S, Lang V, Lorenzen S, Knauer M, Heidenreich S, Xu M, Ripperger JA, Schupp M, Stanewsky R, Kramer A.
Reciprocal regulation of carbon monoxide metabolism and the circadian clock.
Nat Struct Mol Biol. 2016 Nov 28. doi: 10.1038/nsmb.3331. [Epub ahead of print][PubMed Link]

Pivovarova O, Gögebakan Ö, Sucher S, Groth J, Murahovschi V, Kessler K, Osterhoff M, Rudovich N, Kramer A, Pfeiffer AF.
Regulation of the clock gene expression in human adipose tissue by weight loss.
Int J Obes (Lond). 2016 Feb 23. doi: 10.1038/ijo.2016.34. [Epub ahead of print][PubMed Link]

2015

Saleh M, Jürchott K, Oberland S, Neuhaus EM, Kramer A, Abraham U.
Genome-Wide Screen Reveals Rhythmic Regulation of Genes Involved in Odor Processing in the Olfactory Epithelium.
J Biol Rhythms. 2015 Dec;30(6):506-18. doi: 10.1177/0748730415610197. Epub 2015 Oct 19.[PubMed Link]

Korge S, Grudziecki A, Kramer A.
Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells.
J Biol Rhythms. 2015 Oct;30(5):389-95. doi: 10.1177/0748730415597519. Epub 2015 Aug 4.[PubMed Link]

Bordyugov G, Abraham U, Granada A, Rose P, Imkeller K, Kramer A, Herzel H.
Tuning the phase of circadian entrainment.
J R Soc Interface. 2015 Jul 6;12(108). pii: 20150282. doi: 10.1098/rsif.2015.0282.[PubMed Link]

Reischl S, Kramer A.
Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock.
J Biol Rhythms. 2015 Aug;30(4):291-301. doi: 10.1177/0748730415587407. Epub 2015 Jun 2.[PubMed Link]

Wallach T, Kramer A.
Chemical chronobiology: Toward drugs manipulating time.
FEBS Lett. 2015 Jun 22;589(14):1530-1538. doi: 10.1016/j.febslet.2015.04.059. Epub 2015 May 7.[PubMed Link]

Pivovarova O, Jürchott K, Rudovich N, Hornemann S, Ye L, Möckel S, Murahovschi V, Kessler K, Seltmann AC, Maser-Gluth C, Mazuch J, Kruse M, Busjahn A, Kramer A, Pfeiffer AF.
Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans.
J Clin Endocrinol Metab. 2015 Jun;100(6):2291-302. doi: 10.1210/jc.2014-3868. Epub 2015 Mar 30.[PubMed Link]

Kramer A.
Circadian rhythms. When the circadian clock becomes blind.
Science. 2015 Jan 30; 347 (6221):476-7.doi: 10.1126/science.aaa5085.[Full Text]

Spies CM, Hoff P, Mazuch J, Gaber T, Maier B, Strehl C, Hahne M, Jakstadt M, Huscher D, Burmester GR, Detert J, Kramer A, Buttgereit F.
Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study.
Clin Exp Rheumatol. 2015 Mar-Apr;33(1)34-43. Epub 2014 Dec 22 [PubMed Link]

2014

Lee E, Jeong EH, Jeong HJ, Yildirim E, Vanselow JT, Ng F, Liu Y, Mahesh G, Kramer A, Hardin PE, Edery I, Kim EY.
Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.
PLos Genet. 2014 Aug 14;10(8):e1004545. doi: 10.1371/journal.pgen.1004545. eCollection 2014.[PubMed Link]

Ollinger R, Korge S, Korte T, Koller B, Herrmann A, Kramer A.
Dynamics of the circadian clock protein PERIOD2 in living cells.
J Cell Sci. 2014 Oct 1;127(Pt 19):4322-8. doi: 10.1242/jcs.156612. Epub 2014 Jul 29.[PubMed Link]

Relógio A, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C
Ras-mediated deregulation of the circadian clock in cancer.
PLos Genet. 2014 May 29;10(5):e1004338. doi: 10.1371/journal.pgen.1004338. eCollection 2014 May.[PubMed Link]

Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A*, Wolf E*.
Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation.
Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057.[PubMed Link] (*=corresponding author)

Azzi A, Dallmann R, Casserly A, Rehrauer H, Patrignani A, Maier B, Kramer A, Brown SA.
Circadian behavior is light-reprogrammed by plastic DNA methylation.
Nat Neurosci. 2014 Feb 16. doi: 10.1038/nn.3651. [Epub ahead of print][PubMed Link]

2013

Anna Czarna, Alex Berndt, Hari Raj Singh, Astrid Grudziecki, Andreas G. Ladurner, Gyula Timinszky, Achim Kramer, Eva Wolf
Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function.
Cell. 2013 Jun 6;153(6):1394-405. doi: 10.1016/j.cell.2013.05.011.[PubMed Link]

Granada AE, Bordyugov G, Kramer A, Herzel H
Human chronotypes from a theoretical perspective.
PloS One. 2013;8(3):e59464. doi: 10.1371/journal.pone.0059464. Epub 2013 Mar 27.[PubMed Link]

Wallach T, Schellenberg K, Maier B, Kalathur R, Porras P, Wanker EE, Futschik M, Kramer A
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
PloS Genetics 2013 Mar;9(3):e1003398. doi: 10.1371/journal.pgen.1003398. Epub 2013 Mar 28.[PubMed Link]

Abraham U, Saleh M, Kramer A
Odor is a time cue for circadian behavior.
J Biol Rhythms. 2013 Feb;28(1):26-37. doi: 10.1177/0748730412469353.[PubMed Link]

Maier B, Kramer A
A NONO-gate times the cell cycle.
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1565-6. doi: 10.1073/pnas.1221057110. Epub 2013 Jan 16.[PubMed Link]

2012

Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, Kramer A, Brown SA
Distinct roles of DBHS family members in the circadian transcriptional feedback loop.
Mol Cell Biol. 2012 Nov;32(22):4585-94. doi: 10.1128/MCB.00334-12. Epub 2012 Sep 10.[PubMed Link]

Spörl F, Korge S, Jürchott K, Wunderskirchner M, Schellenberg K, Heins S, Specht A, Stoll C, Klemz R, Maier B, Wenck H, Schrader A, Kunz D, Blatt T, Kramer A.
Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes.
Proc Natl Acad Sci U S A. Epub ahead of print (2012 Jun 18) [PubMed Link]

Kucera N, Schmalen I, Hennig S, Öllinger R, Strauss HM, Grudziecki A, Wieczorek C, Kramer A, Wolf E.
Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function.
Proc Natl Acad Sci U S A. 109(9):3311-6. (2012 Feb 28) [PubMed Link]

2011

Relógio A, Westermark PO, Wallach T, Schellenberg K, Kramer A, Herzel H
Tuning the mammalian circadian clock: robust synergy of two loops.
Plos Comput Biol 7(12):e1002309. (2011 Dec 15) [PubMed Link]

Spörl F, Schellenberg K, Blatt T, Wenck H, Wittern KP, Schrader A, Kramer A
A Circadian Clock in HaCaT Keratinocytes.
J Invest Dermatol. 131(2):338-48. (2010 Oct 21) [PubMed Link]

Teschke M, Wendt S, Kawaguchi S, Kramer A*, Meyer B.
A Circadian Clock in Antarctic Krill: An Endogenous Timing System Governs Metabolic Output Rhythms in the Euphausid Species Euphausia superba.
PLoS One 6:e26090. (2011 Oct 7) [PubMed Link] (*=corresponding author)

Schmutz I, Wendt S, Schnell A, Kramer A, Mansuy IM, Albrecht U.
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
PLoS One 6:e21325 (2011 Jun 21) [PubMed Link]

Reischl S, Kramer A.
Kinases and phosphatases in the mammalian circadian clock.
FEBS Lett. 585:1393-9 (2011 Mar 3) [PubMed Link]

2010

Abraham U, Granada AE, Westermark PO, Heine M, Kramer A, Herzel H
Coupling governs entrainment range of circadian clocks.
Mol Syst Biol. 6:438 (2010 Nov 30) [PubMed Link]

Ko HW, Kim EY, Chiu J, Vanselow JT, Kramer A, Edery I
A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3beta/SGG in circadian clocks.
J Neurosci. 30(38):12664-75 (2010 Sep 22) [PubMed Link]

2009

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD, Kramer A*, Maier B
A circadian clock in macrophages controls inflammatory immune responses.
Proc Natl Acad Sci USA. 106(50):21407-12. (2009 Dec 1) [PubMed Link] (*=corresponding author)

Hennig S, Strauss HM, Vanselow K, Yildiz O, Schulze S, Arens J, Kramer A, Wolf E
Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2.
PLoS Biol. 7(4):e94. (2009 Apr 28) [PubMed Link]

Bozek K, Kielbasa SM, Relógio A, Heine M, Dame C, Kramer A, Herzel H
Regulation of clock controlled genes in mammals.
PLoS ONE 4(3):e4882 (2009 Mar 16) [PubMed Link]

Maier B, Wendt S, Vanselow JT, Wallach T, Reischl S, Oehmke S, Schlosser A, Kramer A
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
Genes Dev. 2009, 23:708-718 (2009 Mar 15) [PubMed Link]

2008

Chiu JC, Vanselow JT, Kramer A, Edery I.
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.
Genes Dev. 22(13):1758-72. (2008 Jul 1) [PubMed Link]

Locke JC, Westermark PO, Kramer A, Herzel H.
Global parameter search reveals design principles of the mammalian circadian clock.
BMC Syst Biol. 2(1):22. (2008 Feb 29) [PubMed Link]

Brown SA, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A
Molecular insights into human daily behavior.
PNAS. 105(5):1602-7. (2008 Feb 5) [PubMed Link]

2007

Vanselow K, Kramer A.
Role of phosphorylation in the mammalian circadian clock.
Cold Spring Harb Symp Quant Biol. 72:167-76. (2007) [PubMed Link]

Bozek K, Kielbasa SM, Kramer A, Herzel H.
Promoter analysis of Mammalian clock controlled genes.
Genome Inform. 18:65-74. (2007) [PubMed Link]

Schlosser A, Vanselow JT, Kramer A
Comprehensive Phosphorylation Site Analysis of Individual Phosphoproteins Applying Scoring Schemes for MS/MS Data.
Anal Chem. 79(19):7439-49. (2007 Oct 1) [Pubmed Link]

Reischl S, Vanselow K, Westermark PO, Thierfelder N, Maier B, Herzel H, Kramer A
ß-TrCP1 mediated degradation of PERIOD2 is essential for circadian dynamics.
J Biol Rhythms. 22(5):375-86. (2007 Oct) [Pubmed Link]

Bernard S, Gonze D, Cajavec B, Herzel H, Kramer A (2007)
Synchronization-Induced Rhythmicity of Circadian Oscillators in the Suprachiasmatic Nucleus.
Plos Comput Biol. 3(4):e68. (2007 Apr 13) [Pubmed Link]

Zhao W-N, Malinin N, Yang F-C, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ
CIPC is a mammalian circadian clock protein without invertebrate homologs.
Nature Cell Biol. 9(3):268-75. (2007 Mar) [Pubmed Link]

2006

Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A. (2006).
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
Genes Dev. 20(19):2660-72. (2006 Oct 1) [Pubmed Link]

2005

Schlosser A, Vanselow JT, Kramer A
Mapping of phosphorylation sites by a multi-protease approach with specific phosphopeptide enrichment and NanoLC-MS/MS analysis.
Anal Chem. 77(16):5243-50. (2005 Aug 15) [Pubmed Link]

Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H
Spontaneous synchronization of coupled circadian oscillators.
Biophys J. 89(1):120-9. (2005 Apr 22) [Pubmed Link]

Geier, F., Becker-Weimann, S., Kramer, A. and Herzel, H
Entrainment in a model of the mammalian circadian oscillator.
J Biol Rhythms. 20(1):83-93. (2005 Feb) [Pubmed Link]

Kramer A, Yang FC, Kraves S, Weitz CJ
A screen for secreted factors of the suprachiasmatic nucleus.
Methods Enzymol. 393:645-63. (2005) [Pubmed Link]

2004

Becker-Weimann S, Wolf J, Herzel H, Kramer A
Modeling feedback loops of the mammalian circadian oscillator.
Biophys J. 87(5):3023-34. (2004 Sep 3) [Pubmed Link]

2001

Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling.
Science 294, 2511-2515. (2001 Dec 21) [Pubmed Link]




selected publications in other fields of research

Portwich M, Keller S, Strauss HM, Mahrenholz CC, Kretzschmar I, Kramer A, Volkmer R (2007).
A network of coiled-coil associations derived from synthetic GCN4 leucine zipper arrays.
Angewandte Chemie Int Ed. 2007;46(10):1654-7. [Pubmed Link]

Hoffmüller U., Knaute T., Hahn M., Höhne W., Schneider-Mergener J., Kramer A. (2000).
Evolutionary transition pathways for changing peptide ligand specificity and structure.
EMBO J. 19, 4866-4874. [Pubmed Link]

Maier, B., Molinger, M., Cope, A. P., Fugger, L., Schneider-Mergener, J., S�nderstrup, G., Kamradt, T., and Kramer, A. (2000).
Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.
Eur J Immunol. 30, 448-457. [Pubmed Link]

Winkler, K., Kramer, A., Küttner, G., Seifert, M., Scholz, C., Wessner, H. Schneider-Mergener, J. and Höhne, W. (2000).
Changing the antigen binding specificity by single point mutations of an anti-p24 (HIV-1) antibody.
J Immunol. 165, 4506-4514. [Pubmed Link]

Kramer, A. and Schneider-Mergener, J. (1998).
Synthesis and application of peptide libraries bound to continuous cellulose membranes.
Meth Mol Biol. 87, 25-39. [Pubmed Link]

Kramer, A., Keitel, T., Höhne, W. and Schneider-Mergener, J. (1997).
Molecular basis of the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody.
Cell. 91, 799-809. [Pubmed Link]

Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J. and Höhne, W. (1997).
Crystallographic analysis of of an anti-p24 (HIV-1) monoclonal antibody cross reactivity and polyspecificity.
Cell. 91, 811-820. [Pubmed Link]