achim kramer lab

:research .interests .chronoimmunology



home

research
    .interests
       .chronoimmunology

people

publications

jobs

contact

links

journal club

project seminar

lectures


Dr. Bert Maier
Senior scientist

phone: 450-52 42 64
e-mail: bert.maier@charite.de

Our chronoimmunology team is interested in circadian rhythms in the immunesystem. Where are these rhythms apparent? Which immune functions are controlled by the circadian clock? How are rhythmic immune functions connected to the circadian system on the molecular level and what is the biological significance of circadian rhythms in the immune system?
We approach these questions using cell culture models as well as mouse models of the innate immune system. One of our projects funded by the DFG addresses the circadian clock in macrophages: what are the mechanisms of immune regulation in these cells and what are the pathophysiological implications? Another project started just recently deals with the circadian clock in the host defense against malaria. This project is funded by the Human Frontier Science Program (HFSP) and is part of an international and interdisciplinary research effort, elucidating the evolutionary ecology of chronobiology in host-parasite interactions.



Publications

Thurley K, Herbst C, Wesener F, Koller B, Wallach T, Maier B, Kramer A, Westermark PO.
Principles for circadian orchestration of metabolic pathways.
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1572-1577. doi: 10.1073/pnas.1613103114.[PubMed Link]

Penter L, Maier B, Frede U, Hackner B, Carell T, Hagemeier C, Truss M
A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.
Targeted oncology 2015 Dec;10(4):523-33. doi: 10.1007/s11523-014-0354-5. [PubMed Link]

Spies CM, Hoff P, Mazuch J, Gaber T, Maier B, Strehl C, Hahne M, Jakstadt M, Huscher D, Burmester GR, Detert J, Kramer A, Buttgereit F
Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study.
Clin Exp Rheumatol. 2015 Mar-Apr; 33(1) 34-43. Epub 2014 Dec 22 [PubMed Link]

Azzi A, Dallmann R, Casserly A, Rehrauer H, Patrignani A, Maier B, Kramer A, and Brown SA
Circadian behavior is light-reprogrammed by plastic DNA methylation.
Nature Neuroscience 2014; 17, 377-382 [PubMed Link]

Relógio A, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C
Ras-mediated deregulation of the circadian clock in cancer.
PLos Genet. 2014 May 29; 10(5):e1004338. doi: 10.1371/journal.pgen.1004338. eCollection 2014 May.[PubMed Link]

Wallach T, Schellenberg K, Maier B, Kalathur R, Porras P, Wanker EE, Futschik M, Kramer A
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
PloS Genetics 2013; 9(3):e1003398. doi: 10.1371/journal.pgen.1003398. Epub 2013 Mar 28..[PubMed Link]

Maier B, Kramer A
A NONO-gate times the cell cycle.
Proc Natl Acad Sci U S A 2013; 110(5):1565-6 [PubMed Link]

Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, Kramer A, and Brown SA
Distinct Roles of DBHS Family Members in the Circadian Transcriptional Feedback Loop. Molecular and cellular biology.
MCB 2012; 32, 45854594 [PubMed Link]

Spörl F, Korge S, Jürchott K, Wunderskirchner M, Schellenberg K, Heins S, Specht A, Stoll C, Klemz R, Maier B, Wenck H, Schrader A, Kunz D, Blatt T, Kramer A
Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes.
Proc Natl Acad Sci U S A 2012; 109, 1090310908 [PubMed Link]

Maier B, Wendt S, Vanselow JT, Wallach T, Reischl S, Oehmke S, Schlosser A, and Kramer A
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
Genes Dev 2009; 23, 708718 [PubMed Link]

Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk H-D, Kramer A, and Maier B
A circadian clock in macrophages controls inflammatory immune responses.
Proc Natl Acad Sci U S A 2009; 106, 2140721412 [PubMed Link]

Reischl S, Vanselow K, Westermark PO, Thierfelder N, Maier B, Herzel H, Kramer A
ß-TrCP1 mediated degradation of PERIOD2 is essential for circadian dynamics.
J Biol Rhythms 2007; 22(5):375-86 [Pubmed Link]

Zhao W-N, Malinin N, Yang F-C, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ
CIPC is a mammalian circadian clock protein without invertebrate homologs.
Nature Cell Biol 2007; 9(3):268-75 [Pubmed Link]

Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A.
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
Genes Dev 2006; 20(19):2660-72 [Pubmed Link]

Schubert D, Maier B, Morawietz L, Krenn V, and Kamradt T
Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice.
J Immunol 2004; 172, 45034509 [Pubmed Link]

Maier B, Molinger M, Cope AP, Fugger L, Schneider-Mergener J, Sonderstrup, G., Kamradt, T., and Kramer, A.
Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells.
Eur J Immunol 2000; 30, 448-457 [Pubmed Link]